Medullary vasomotor center: a modern view of the structure, function and its role in arterial hypertension pathogenesis

The medullary centers of blood pressure regulation have been in the field vision both physiologists and doctors for a very long period time. This is mainly due to abundance structures interstructural interactions brain stem, involved maintaining pressure. Advances research technology open new opportunities these days look at this problem from different angle. Moreover, will make it possible understand better mechanisms persistent increase pressure, which create preconditions formation pathogenetically substantiated therapeutic approaches treatment such widespread dangerous pathology as arterial hypertension. Therefore, aim work was analyze modern views about structure composition vasomotor center, its functions role hypertension development. To achieve goal, search by keywords: hypertension, baroreflex, NTS, DMN, RVLM, CVLM, CPA, SHR, LC analysis scientific articles databases engines Google Scholar, Web Science, Pub Med done. Conclusions: 1. literature sources showed that concept "medullar center" includes number brainstem formations, most studied are dorsal complex vagus nerve (the nucleus solitary tract, motor nucleus, area postrema), rostral caudal ventrolateral regions medulla, pressor area, noradrenergic brainstem, particular locus coeruleus, biggest them. 2. According literary sources, accompanied changes morphofunctional state above-mentioned structures. common violation neurotransmitter within neuroinflammatory process.